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Thursday, July 30, 2020 | History

3 edition of Aging of the organism at the molecular level found in the catalog.

Aging of the organism at the molecular level

Zhores A. Medvedev

Aging of the organism at the molecular level

a translation from the Russian.

by Zhores A. Medvedev

  • 23 Want to read
  • 28 Currently reading

Published by U. S. Dept. of Health, Education, and Welfare, Public Health Service] sponsored and distributed by Center for Aging Research, Division of General Medical Sciences, National Institutes of Health and National Library of Medicine, Bethesda, Md. in [Washington .
Written in English

    Subjects:
  • Aging.,
  • Proteins -- Metabolism.,
  • Nucleic acids.

  • Classifications
    LC ClassificationsQP86 .M53, QP86 .M53
    The Physical Object
    Pagination23 p.
    Number of Pages23
    ID Numbers
    Open LibraryOL14188895M
    LC Control Number62064768

      Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. Description: Molecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series focuses on the nutritional issues associated with aging and the important metabolic consequences of diet, nutrition, and health. The book is subdivided into four parts that reflect the impact of nutrition from a biomolecular level to individual health.

      The Molecular Genetics of Aging (Results and Problems in Cell Differentiation Book 29) - Kindle edition by Hekimi, Siegfried. Download it once and read it on your Kindle device, PC, phones or tablets. Use features like bookmarks, note taking and highlighting while reading The Molecular Genetics of Aging (Results and Problems in Cell Differentiation Book 29).Reviews: 1. Summary: Genes and Aging • Single gene mutations can extend lifespan • Amazingly, aging pathways are conserved across 1 billion years of evolution • Aging genes and calorie restriction affect the same biological pathways – Is there a single regulatory pathway for lifespan?

    Chronological age is a measure of how long an organism has been alive, while biological age is a measure of how well the organism is functioning on a molecular level. Molecular Theories of Aging. Aging is the most universal of biological phenomena known to man. It has been studied since the beginning of man. Million of books have been written to try and explain it. People have devoted their lives to conquer it. The Bible explains aging as .


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Aging of the organism at the molecular level by Zhores A. Medvedev Download PDF EPUB FB2

Molecular and Cellular Biology of Aging The approach in generating this comprehensive textbook has been to compare aging at the cellular and microbiological levels across multiple forms of life.

It is now clear that the vast majority of living organisms display some aspects of aging, many of which appear to be conserved throughout evolution. Aging of the organism at the molecular level: a translation from the Russian.

[Zhores A Medvedev] Print book: National government publication: EnglishView all editions and formats: Rating: (not yet rated) 0 with reviews - Be the first. Subjects: Aging. Proteins -- Metabolism. Abstract. Aging is the largest risk factor for many diseases, and the aging population is one of the fastest growing in the Western world.

Therefore it has become ever more important to improve our understanding of cellular and molecular mechanisms that underlie human aging to promote healthy aging.

At the molecular level, a number of mechanisms have been identified that are believed to underlie the damage-induced aging process including somatic mutations, telomere shortening, protein Author: Thomas Von Zglinicki.

Aging at the Molecular Level examines the key elements in this transformation. Bringing together contributions from an international team of authors, this volume will be of interest to graduates and postgraduates in the fields of medicine and nursing, researchers of different aspects of biogerontology and those in the pharmaceutical Author: Thomas Von Zglinicki.

Molecular Genetic Mechanisms in Development and Aging discusses the mechanisms of aging at the level of the genome. This book explores the fundamental knowledge concerning the regulation and expression of gene, which is derived from investigations on microbial organisms.

Organized into nine chapters, this book starts with an overview of the. Aging takes place in a cell, an organ, or the total organism with the passage of is a process that goes on over the entire adult life span of any living thing.

Gerontology, the study of the aging process, is devoted to the understanding and control of all factors contributing to the finitude of individual is not concerned exclusively with debility, which looms so large in human.

• Aging at the Cellular and Molecular Level organisms are immortalorganisms are immortal • In multicellular organisms, senescence occurs in those that undergo somatic celloccurs in those that undergo somatic cell differentiation Masoro, E in Handbook of Physiology, Aging, Section.

The molecular basis of ageing was therefore a timely and exciting topic for the Boehringer Ingelheim Fonds International Titisee Conference. Molecular causes of ageing At a fundamental level, biological ageing can be thought of as a progressive decline in the function of the cells of an organism, ultimately resulting in senescence.

Aging reflects long-term decline in physiological function and integrity. Changes arise at a variable pace governed by time-dependent and -independent mechanisms that are themselves complex, interdependent and variable.

Molecular decay produces inferior cells that eventually dominate over healthy counterparts in tissues they comprise. Molecular Genetic Mechanisms in Development and Aging discusses the mechanisms of aging at the level of the genome.

This book explores the fundamental knowledge concerning the regulation and expression of gene, which is derived from investigations on microbial organisms. HDAC inhibitors are listed as described in the text, along with evidence for the benefits they impart at the molecular level on the hallmarks of aging; epigenetic alterations, telomere attrition, genomic instability, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and.

Each of these is linked to regulation of aging on the cellular level, ultimately impinging on the control of aging of the whole organism. The deeply conserved nature of the IIS pathway, the TOR pathway, and dietary restriction–induced longevity across eukaryotes suggests that regulation of aging is fundamental to eukaryotic evolution.

Senescence (/ s ɪ ˈ n ɛ s ə n s /) or biological aging is the gradual deterioration of functional characteristics. The word senescence can refer either to cellular senescence or to senescence of the whole smal senescence involves an increase in death rates and/or a decrease in fecundity with increasing age, at least in the latter part of an organism's life cycle.

Here we address a small sampling of major constituents of neural function at the cellular and molecular level that play important roles in development and aging, two endogenous processes that embody features of allostasis or the dynamic shifts in set points for specific homeostatic mechanisms associated with development and aging.

words, aging is a major contributor to death rate starting at age Curiously, death rates level off and even decline slightly for extremely old (+) people. Major diseases of aging are so age-dependent they are essentially symptoms of aging. According to U.S./CDC data () an. When we started, research on aging at the molecular level was the backwater of biology, but in the last 25 years, aging has moved to the forefront of science.

It’s actually rare to open a leading scientific journal and not see a new breakthrough in our understanding of the aging process. T he idea that aging follows a somewhat predetermined sequence of events, a program, while debated for decades (1 – 7), has been discredited by most contemporary authors and evolutionary aging theorists, in present, the overwhelming view among experts is that aging derives from multiple forms of molecular damage that steadily accumulate with age and lead to the functional and.

The weakening of the defense in aging organism leads to increase in the level of toxic factors such as reactive oxygen species (ROS), calcium ions, and immuneinflammatory response. The consequence of the change in the level of these molecular factors is the development of age-related diseases, among others, atherosclerosis, tumors and.

The weakening of the defense in aging organism leads to increase in the level of of the molecular factors in aging process is provided in the chapter on protein is contained in this book. aging at the molecular level biology of aging and its modulation series entitled biology of aging and its modulation fulfills the demand for books on the biology of aging which can provide critical and comprehensive overview of the function of the cells of an organism ultimately resulting in senescence despite much study a clear.Molecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series focuses on the nutritional issues associated with aging and the important metabolic consequences of diet, nutrition, and book is subdivided into four parts that reflect the impact of nutrition from a biomolecular level to individual health.

It may help an organism survive." At the molecular level, aging is not always a matter of 'pay later' Your friend's email. Your email. I would like to subscribe to Science X Newsletter.